Nano-enabled stimuli-responsive scaffolds for targeted antimicrobials delivery to treat Staphylococcus aureus infections and restore skin homeostasis - TARDIS

Project summary

Skin infections have a significant impact on human health, especially when they cause disability and disfigurement. Treatments using antibiotics not only select for antimicrobial resistance, a global healthcare treat and heavy economic burden, but also disrupt the protective skin microbiome promoting new or recurrent infections. TARDIS will develop innovative antimicrobial hydrogel scaffolds of targeted bio-based nanoactives with high bactericidal efficacy towards Staphylococcus aureus, the most common skin pathogen, and ability to maintain the beneficial microbial balance and physiological functions of the skin. The environmental and societal impacts of the technologies and products will be considered during the whole lifecycle. The exploitation strategy will harmonize the needs of the society and business in the long term. TARDIS multidisciplinary scientific knowledge and technologies will be easily implemented for a broad range of applications from healthcare to astronomy.