Engineered nano-based device for glioblastoma multiforme therapy - Nano4Glio

Project summary

Rationale / Needs to be addressed Glioblastoma (GBM) is an aggressive brain tumour that is incurable, due to drugs’ low bioavailability in the brain, and resistance mechanisms. Other limitations such as high toxicity reenforce the need for new therapies. Objectives Nano4Glio will develop an implantable device composed of a biodegradable hydrogel incorporating drug-loaded nanoparticles (NPs) for GBM continuous treatment. Potential applications The main application is GBM, but treatment of other neurological diseases may be envisaged for future applications since the NPs surface will be modified with a moiety with affinity for the brain. Impact and potential benefits This project will deliver a suitable approach to improve GBM therapeutic efficacy, allowing for a continuous and enhanced therapy, without the need for daily administration, while overcoming resistance. Thus, Nano4Glio will deliver a pioneering approach that will be able to overcome the limitations of current therapies.