Hybrid biodegradable coating for one-wire peripheral nitinol stent for prevention of restenosis and plaque formation - HybbiStent

Project summary

Peripheral arterial disease (PAD) is caused by atherosclerosis of major vessels supplying the lower extremities and lead to the limited walking ability and reduced quality of life. Self-expanding stents from nitinol revolutionized the treatment of PAD. In spite of significant progress of this technology in the last years, complications, such as in-stent restenosis and re-occlusion rates, are still results of stent implantations. The proposed project HybbiStent aims to develop an unique double-layer coating technology for one-wire peripheral nitinol stent, aimed to minimize the risks of in-stent restenosis and plaque formation due to the use of chemically modified biomimetic lipophilic nanoparticles, carbon-coated iron nanoparticles and detonation nanodiamonds, imitating the structure of natural lipoproteins as anti-restenosis agents. The successful implementation of the project will lead to a competitive product in interventional cardiology with high public value and commercialization.