Advanced magnetic nanoparticles for detection and quantification of biomarkers in biological fluids - BIOMAG

Project summary

An ever-increasing number of medical applications is adopting nanotechnology to go beyond the current state-of-the-art. BioMag aims to provide a quick, sensitive, reliable and low-cost in vitro diagnostic methodology based on functionalised magnetic nanoparticles (F-MNPs) for detection of biomarkers present in bodily fluids. The project aims to 1) design F-MNPs with recognition ligands that specifically interact with cardiac biomarkers related to myocardial infarction and MNP surface engineering to minimize unspecific interactions with off target biomolecules present in blood samples; 2) monitor changes of AC hysteresis loops of F-MNPs after specific interaction with biomarkers; 3) develop numerical simulations to model the variation of the AC hysteresis loops for quantifying the biomarker amount present in the studied sample. The BioMag consortium gathers excellent and multidisciplinary research teams for approaching material science fundamentals towards market applications.