Smart multifunctional Hyaluronic Acid-Carnosine based bandages for wound care and regenerative therapy. - SmartHyCAR
Project summary
An emerging approach for care and regenerative therapy of chronic wounds, which have an increased incidence in elderly, diabetics, immuno-suppressed and immobilised people, uses smart hydrogels for a spatio-temporally triggerred repair process. Hyaluronic acid (HyA)-based dressings are already safely used, e.g., in treating diabetic foot ulcer. The novel multifunctional HyA-CAR(GHK)-Cu dressing, deposited via an atmospheric plasma technology ad hoc designed and developed, starts from HyA conjugated with a dipeptide (carnosine, CAR) and/or a tripeptide (GHK), exhibiting inhibitory effects against carnosinase as well as antioxidant and anti-inflammatory properties. The scaffold is further implemented by the incorporation of copper, which has angiogenic and antibacterial properties, as well as SOD-like activity in the CAR-Cu and GHK-Cu complexes. The HyA-CAR(GHK)-Cu hydrogels will provide a novel unique synergic activity in the modulation of the wound healing and scar repair actions.Project Details
Call
Call 2016
Call Topic
Interfaces between materials and biological hosts for health applications
Project start
01.03.2018
Project end
30.08.2021
Total project costs
1.048.044 €
Total project funding
462.969 €
TRL
1 - 5
Coordinator
Prof. Dr. Cristina Satriano
csatriano@unict.it
University of Catania, viale Andrea Doria, 6 - Edificio 1, 95125 Catania, Italy
Partners and Funders Details
Consortium Partner | Country | Funder | |
---|---|---|---|
University of Catania https://www.unict.it |
University | Italy | IT-MIUR |
Fidia farmaceutici S.p.A. http://www.fidiapharma.com/en/ |
Large industry | Italy | IT-MIUR |
Universitè Libre de Bruxelles https://www.ulb.ac.be |
University | Belgium | BE-SPW |
IONICS http://www.ionics.be/en |
SME | Belgium | BE-SPW |