Nanovectors engineered for plasma enhanced theranostics in regenerative medicine - PNANO4BONE

Project summary

Current scaffolds for regenerative medicine are facing several drawbacks, which are the low proliferation of living cells seeded in the implant, the short duration of drug delivery when drugs are embedded in the scaffold and the impossibility to easily follow the regenerative processes once the scaffold is implanted. The objective of the project is to solve the above mentioned drawbacks by embedding specifically designed nanovectors in the scaffold. The interaction of these nanovectors with tissue-tolerable plasma (ionized gas) will allow promoting the living cell proliferation through the generation of reactive species. The inorganic core of the nanovectors will allow the drug release over weeks/months. The probes loaded in the nanovectors will allow monitoring the regenerative process with non-invasive imaging technologies. If successful in the context of bone regeneration, this approach could be easily adapted to the regeneration of other tissues and lead to lower therapies' costs.