Magnetically and photochemically actuated bioactive nanowires for remotely controlled drug delivery - PAIRED
Project summary
One of the challenges to eradicate tumors is optimizing both drug activity and delivery. Traditional passive treatments of solid tumors are limited by their lack of efficiency, specificity and off-target toxicity due to the poor penetration and non-uniform distribution of the drug inside the tumor mass. Our aim is to achieve a more efficient, spatially and temporally controlled drug delivery nanotechnology by developing innovative bioactive hybrid nanowires as advanced drug carriers that can be magnetically and photochemically actuated. The synergistic magnetic and photochemical actuation will enable guiding and triggering the release of blends of anti-cancer drugs and thermo-sensitive polymers locally inside the tumor, and generating local hyperthermia to boost the therapeutic effects. We expect that the proposed therapeutic nanotechnology will dramatically enhance tissue selectivity and penetration, thereby locally incrementing drug concentration and lethality to reduce side effects.Project Details
Call
Call 2015
Call Topic
Tailoring of bioactive material surfaces for health applications
Project start
01.05.2016
Project end
31.10.2019
Total project costs
532.000 €
Total project funding
345.000 €
TRL
-
Coordinator
Dr. Borja Sepúlveda
borja.sepulveda@icn2.cat
Fundació Institut Català de Nanociència i Nanotecnologia, Campus UAB, ICN2 Building, 08193 Bellaterra, Spain
Partners and Funders Details
Consortium Partner | Country | Funder | |
---|---|---|---|
Fundació Institut Català de Nanociència i Nanotecnologia https://www.icn.cat |
Research org. | Spain | ES-MINECO |
Universidade de Coimbra http://www.uc.pt/ffuc |
University | Portugal | PT-FCT |
The Hebrew University of Jerusalem https://medicine.ekmd.huji.ac.il/schools/pharmacy/En/research/centers/Pages/default.aspx |
University | Israel | IL-MOST IL |